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LH is the direct signal for the testes to produce testosterone

Protein and Sport: Alternative Sources and Strategies for Bioactive and Sustainable Sports Nutrition. Frontiers in Nutrition, 9, 926043

In both GHD and TS, we have identified a baseline gene expression signature in low IGF-I responders

GPxs, which participate in the processes of antioxidant protection and detoxification, are important enzymes that directly regulate ROS levels [28]

Numerous in vitro and in vivo studies have been performed that focused on the modulation of total and free IGF-1 levels and relative impact on tumor growth, invasiveness and response to therapeutics